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KMID : 0367419740150060037
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Journal of Korean Pediatric Society
1974 Volume.15 No. 6 p.37 ~ p.49
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Experimental Study on the Antidiuretic Activity of the Serum of Rabbits treated with Pitrssin
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Abstract
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The author studied the problems whether antidiuretie activity appears in the rabbit serum and also observed the influences of hepatic damage induced by CCl(_4) and premedication with prednisolone on this activity. Korean white male rabbits weghing 1.8 kg were gavaged with 2% sodium chloride solution, 100 ml 3 times hourly for hydration before experiment.
The results were as follows:
1) Sera obtained from the rabbit 5min, 10min and 20min after pitressininjection, were given intravenonsly to normal rabbits which were loaded with water 3times Per Os. Rapid and marked reduction of urine volume were noted in the group of rabbits treated with serum in 10 min ofter pitressin injection while in the cases treated with sera in 5min, 20min and 30min. no change has been shown.
2) No remarkable change of urine volume after pitressin injection was observed in the group of rabbits previously treated with carbon tetracholoride and also antidiuretic activities could hardly be observed in this sera.
3) A decrease of urine volume was demonstrated by pitressin injection in case of prednisolone treated rabbits however it was not remarkable as in normal rabbits. Antidiuretic activities in this sera in these group were also rather weak than in the mormal.
Judging from the results of these experiments, antidiuretic substances appeared secondarily in the rabbits seraafter pitressin injection and were seemed to be formed mainly in the liver.
It is also presumed that prednisolone is suppressive in the formation of antidiuretic substances.
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